Patent
 (2019)

HUMAN ANTIBODY AND FRAGMENTS THEREOF FOR USE IN THE TREATMENT OF GASTRIC CANCER (GC) AND OTHER TYPES OF TUMOURS EXPRESSING THE MICA PROTEIN (MHC CLASS I CHAIN-RELATED PROTEIN A GENE)

MOLINA, MARÍA C; AGUILLÓN, J. CARLOS; Ribeiro, Carolina Hager; Zuñiga, Roberto; Collazo, Norberto; Leiva, Lorenzo; Gutiérrez-González, Matías; Teneb, Jaime; Romero-Trujillo, Alfonso; Jerez, Bastian

Abstract

A bivalent, anti-MICA human monoclonal antibody formed by two or more heavy and light chains with a variable immunoglobulin domain neutralises tile MICA protein in its soluble State and opsonises tumour cells expressing the antigen, stimulating adaptive immunity in the treatment of gastric cáncer or other types of cáncer in which the tumour cells express MICA in the soluble form or abundantiy on their surface.

Más información

Fecha de publicación: 2019
URL: https://patentimages.storage.googleapis.com/c3/91/9e/41a0439f5c575e/WO2019126895A1.pdf
DOI:

WO 2019/126895