Replacement of a proline with silaproline causes a 20-fold increase in the cellular uptake of a pro-rich peptide

Pujals, S; Fernandez-Carneado, J; Kogan, MJ; Martinez, J.; Cavelier, F; Giralt E.

Abstract

The results presented here show that elementary design enhancements have led to a 20-fold increase in the cellular uptake properties of a Pro-rich cell-penetrating peptide. These results are relevant not only due to the increasing interest in using CPPs as molecular shuttles for intracellular drug delivery but also because they illustrate the power of combining conformational analysis with rational design to modulate the behavior of biologically active compounds. © 2006 American Chemical Society.

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Título según WOS: Replacement of a proline with silaproline causes a 20-fold increase in the cellular uptake of a pro-rich peptide
Título según SCOPUS: Replacement of a proline with silaproline causes a 20-fold increase in the cellular uptake of a pro-rich peptide
Título de la Revista: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volumen: 128
Número: 26
Editorial: AMER CHEMICAL SOC
Fecha de publicación: 2006
Página de inicio: 8479
Página final: 8483
Idioma: English
URL: http://pubs.acs.org/doi/abs/10.1021/ja060036c
DOI:

10.1021/ja060036c

Notas: ISI, SCOPUS