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Nanobody tool kit to unravel autophagosomal biogenesis
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| Fecha de publicación: | 2019 |
| Objetivos: | Objective 1: Generate antigens of the ATG12 and LC3 conjugation system for nanobody production Objective 2: Generate and select nanobodies targeting the ATG12 and LC3 conjugation system Objective 3: Apply nanobodies for the functional and mechanistic characterization of the ATG12/LC3 conjugation |
| Programa: | PCI |
| Año de Inicio/Término: | 2019-2022 |
| Financiamiento/Sponsor: | CONICYT |
| Rol del Usuario: | COINVESTIGADOR(A) |
| URL: | https://www.biochem.mpg.de/schulman |
| DOI: |
MPG190011 |
| Notas: | A widespread mechanism regulating the functions of eukaryotic proteins involves post-translational modification by the small protein ubiquitin (UB) or structurally related ubiquitin-like proteins (UBLs). Covalent linkage of ubiquitin and UBLs can lead to rapid changes in a protein’s half-life |