Mild and rapid method for the generation of o-quinone methide intermediates. Synthesis of puupehedione analogues

Barrero, AF; del Moral, JFQ; Herrador, MM; Arteaga P.; Cortes, M; Benites, J.; Rosellon, A

Abstract

A route to simpler analogues to bioactive puupehedione derivatives involving a hetero Diels-Alder cycloaddition of a o-quinone methide is described. These intermediate species are generated via fluoride-induced desilylation of silyl derivatives of o-hydroxybenzyl iodides. Remarkable short reaction times and very mild experimental conditions are the main features of this method. © 2006 Elsevier Ltd. All rights reserved.

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Título según WOS: Mild and rapid method for the generation of o-quinone methide intermediates. Synthesis of puupehedione analogues
Título según SCOPUS: Mild and rapid method for the generation of o-quinone methide intermediates. Synthesis of puupehedione analogues
Título de la Revista: TETRAHEDRON
Volumen: 62
Número: 25
Editorial: PERGAMON-ELSEVIER SCIENCE LTD
Fecha de publicación: 2006
Página de inicio: 6012
Página final: 6017
Idioma: English
URL: http://linkinghub.elsevier.com/retrieve/pii/S0040402006005588
DOI:

10.1016/j.tet.2006.04.004

Notas: ISI, SCOPUS