The Therapeutic Potential of Anthocyanins: Current Approaches Based on Their Molecular Mechanism of Action

Salehi, Bahare; Sharifi-Rad, Javad; Cappellini, Francesca; Reiner, Zeljko; Zorzan, Debora; Imran, Muhammad; Sener, Bilge; Kilic, Mehtap; El-Shazly, Mohamed; Fahmy, Nouran M.; Al-Sayed, Eman; Martorell, Miquel; Tonelli, Chiara; Petroni, Katia; Docea, Anca Oana; et. al.

Abstract

Anthocyanins are natural phenolic pigments with biological activity. They are well-known to have potent antioxidant and antiinflammatory activity, which explains the various biological effects reported for these substances suggesting their antidiabetic and anticancer activities, and their role in cardiovascular and neuroprotective prevention. This review aims to comprehensively analyze different studies performed on this class of compounds, their bioavailability and their therapeutic potential. An in-depth look in preclinical,in vitroandin vivo, and clinical studies indicates the preventive effects of anthocyanins on cardioprotection, neuroprotection, antiobesity as well as their antidiabetes and anticancer effects.

Más información

Título según WOS: The Therapeutic Potential of Anthocyanins: Current Approaches Based on Their Molecular Mechanism of Action
Título de la Revista: FRONTIERS IN PHARMACOLOGY
Volumen: 11
Editorial: FRONTIERS MEDIA SA
Fecha de publicación: 2020
DOI:

10.3389/fphar.2020.01300

Notas: ISI