Article ISI SCOPUS
Developmental Cell  (2020)

Functional Diversification of SRSF Protein Kinase to Control Ubiquitin-Dependent Neurodevelopmental Signaling

Bustos, Francisco; Segarra-Fas, Anna; Nardocci, Gino; Cassidy, Andrew; Antico, Odetta; Davidson, Lindsay; Brandenburg, Lennart; Macartney, Thomas J.; Toth, Rachel; Hastie, C. James; Moran, Jennifer; Gourlay, Robert; Varghese, Joby; Soares, Renata F.; Montecino, Martin; et. al.

Abstract

Bustos et al. show that SRPK splicing factor kinase has acquired a developmental function— phosphorylating the RNF12 E3 ubiquitin ligase to promote degradation of the transcription factor, REX1. This signaling pathway regulates a neurodevelopmental gene expression program and is mutated in patients with neurodevelopmental disorders.

Más información

Título según WOS: Functional Diversification of SRSF Protein Kinase to Control Ubiquitin-Dependent Neurodevelopmental Signaling
Título según SCOPUS: Functional Diversification of SRSF Protein Kinase to Control Ubiquitin-Dependent Neurodevelopmental Signaling
Título de la Revista: Developmental Cell
Volumen: 55
Número: 5
Editorial: Cell Press
Fecha de publicación: 2020
Página final: 647.e7
Idioma: English
DOI:

10.1016/j.devcel.2020.09.025
Notas: ISI, SCOPUS