Targeting n-3 Polyunsaturated Fatty Acids in Non-Alcoholic Fatty Liver Disease

Valenzuela, Rodrigo.; Ortiz, Macarena; Catalina Hernandez-Rodas, Maria; Echeverria, Francisca; Videla, Luis Alberto

Abstract

Background: Non-Alcoholic Fatty Liver Disease (NAFLD) is characterized by abnormal hepatic accumulation of triacylglycerides in the absence of alcohol consumption, in association with Oxidative Stress (OS), a pro-inflammatory state and Insulin Resistance (IR), which are attenuated by n-3 long-chain polyunsaturated Fatty Acids (FAs) C20-C22 (LCPUFAs) supplementation. Main causes of NAFLD comprise high caloric intake and a sedentary lifestyle, with high intakes of saturated FAs.

Más información

Título según WOS: Targeting n-3 Polyunsaturated Fatty Acids in Non-Alcoholic Fatty Liver Disease
Título de la Revista: CURRENT MEDICINAL CHEMISTRY
Volumen: 27
Número: 31
Editorial: BENTHAM SCIENCE PUBL LTD
Fecha de publicación: 2020
Página de inicio: 5250
Página final: 5272
DOI:

10.2174/0929867326666190410121716

Notas: ISI