COST-BENEFIT-ANALYSIS FOR THE USE OF HAEMOPHILUS-INFLUENZAE TYPE-B CONJUGATE VACCINE IN SANTIAGO, CHILE

LEVINE, OS; ORTIZ, E; CONTRERAS, R; LAGOS, R; VIAL, P; MISRAJI, A; FERRECCIO, C; ESPINOZA, C; ADLERSTEIN, L; HERRERA, P; CASAR, C

Abstract

Cost-benefit analyses can be integral to the evaluation of interventions in developing countries. The authors compare the potential benefits to the Chilean Ministry of Health, in terms of treatment costs averted, by prevention of Haemophilus influenzae type b (HIB) invasive disease, with the costs of adding HIB conjugate vaccine to the diphtheria-tetanus-pertussis (DTP) immunization routinely administered to infants. In their base-case model, over a 10-year period (1991-2000), vaccination against HIB will prevent 1,229 cases of HIB invasive disease, including 713 cases of meningitis, 107 of whom would suffer severe, long-term sequelae, and between 29 and 116 deaths. Assuming a cost of US$1 for a full three-dose regimen of vaccine, the benefit/cost ratio of 1.66, with a net discounted savings of over $403,225, illustrates that HIB vaccine can be cost-beneficial. Sensitivity analyses which alter each of the variables in the analysis indicate that if the true incidence of HIB disease is twice the published rate, then three doses of vaccine remains cost-beneficial at US$3.

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Título según WOS: ID WOS:A1993LM33700006 Not found in local WOS DB
Título de la Revista: AMERICAN JOURNAL OF EPIDEMIOLOGY
Volumen: 137
Número: 11
Editorial: OXFORD UNIV PRESS INC
Fecha de publicación: 1993
Página de inicio: 1221
Página final: 1228
DOI:

10.1093/oxfordjournals.aje.a116624

Notas: ISI