Article ISI
THERANOSTICS  (2021)

The ATP synthase inhibition induces an AMPK-dependent glycolytic switch of mesenchymal stem cells that enhances their immunotherapeutic potential

Contreras-Lopez, Rafael; Elizondo-Vega, Roberto; Luque-Campos, Noymar; Torres, Maria Jose; Pradenas, Carolina; Tejedor, Gautier; Jose Paredes-Martinez, Maria; Maria Vega-Letter, Ana; Campos-Mora, Mauricio; Rigual-Gonzalez, Yandi; Oyarce, Karina; Salgado, Magdiel; Jorgensen, Christian; Khoury, Maroun; de los Angeles Garcia-Robles, Maria; et. al.

Abstract

Objectives: Mesenchymal Stem/Stromal Cells (MSC) are promising therapeutic tools for inflammatory diseases due to their potent immunoregulatory capacities. Their suppressive activity mainly depends on inflammatory cues that have been recently associated with changes in MSC bioenergetic status towards a glycolytic metabolism. However, the molecular mechanisms behind this metabolic reprogramming and its impact on MSC therapeutic properties have not been investigated.

Más información

Título según WOS: The ATP synthase inhibition induces an AMPK-dependent glycolytic switch of mesenchymal stem cells that enhances their immunotherapeutic potential
Título de la Revista: THERANOSTICS
Volumen: 11
Número: 1
Editorial: IVYSPRING INT PUBL
Fecha de publicación: 2021
Página de inicio: 445
Página final: 460
DOI:

10.7150/THNO.51631
Notas: ISI