Laminin inhibits amyloid-beta-peptide fibrillation

Bronfman, FC; Garrido, J; Alvarez, A; Morgan, C; Inestrosa, NC

Abstract

Laminin, an important extracellular matrix component is induced by brain injury and colocalizes with amyloid-beta-peptide (A beta) deposits in Alzheimer brains. We report here that laminin inhibits amyloid fibril formation as determined by thioflavin T fluorescence spectroscopy and electron microscopic examination. The inhibition of amyloid formation by laminin was concentration dependent and was observed at a laminin concentration of 300 nM, corresponding to a laminin/A beta protein molar ratio of 1:800. The potential effect of laminin, may prove important to inhibit AP fibrillogenesis in vivo, specifically at the level of cerebral blood vessels.

Más información

Título según WOS: ID WOS:A1996VU69600015 Not found in local WOS DB
Título de la Revista: NEUROSCIENCE LETTERS
Volumen: 218
Número: 3
Editorial: ELSEVIER IRELAND LTD
Fecha de publicación: 1996
Página de inicio: 201
Página final: 203
DOI:

10.1016/S0304-3940(96)13147-5

Notas: ISI