Anaplastic large cell lymphoma associated with breast implants, diagnosed by fine needle aspiration. Report of one case

Misad S, Carlos; Walker B, Kenneth; Valbuena, Jose R.; Guerra S, Claudio; Camus A, Mauricio; Ocqueteau, Mauricio; Loyola, Sandra; Zoroquiain, Pablo

Abstract

Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a rare type of non-Hodgkin T-cell lymphoma, recently defined in the 2016 World Health Organization (WHO) classification of lymphoid neoplasms. It occurs more commonly when textured implants are used and appears clinically as a late seroma. Cytologically, these lesions are composed of large atypical cells with pleomorphic nucleus and an immunophenotype positive for T cell markers and CD30, and negative for ALK1. We report a 56-years-old woman with breast implants who developed a periprosthetic seroma three years after surgery. A fine needle aspiration of the lesion was carried out. Cytology and the immunocytochemical study revealed cells compatible with BIA-ALCL. The flow cytometric study was negative. Excisional biopsy of the capsule was performed, observing that the neoplastic cells were confined to the inner surface of the capsule. Imaging studies did not find evidence of disseminated disease. The present case demonstrates the importance of the study of any late periprosthetic effusion, which can be performed using fine needle aspiration.

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Título según WOS: Anaplastic large cell lymphoma associated with breast implants, diagnosed by fine needle aspiration. Report of one case
Título de la Revista: REVISTA MEDICA DE CHILE
Volumen: 148
Número: 8
Editorial: SOC MEDICA SANTIAGO
Fecha de publicación: 2020
Página de inicio: 1207
Página final: 1212
Notas: ISI