Experimental Analyses Emphasize the Stability of the Meisenheimer Complex in a SNAr Reaction Toward Trends in Reaction Pathways

Campodonico, Paola R.; Olivares, Belen; Tapia, Ricardo A.

Abstract

The mechanism of SNAr reactions between 2-chloro-5-nitropyrimidine with primary and secondary alicyclic amines, respectively, have been studied by kinetic measurements. The kinetic data obtained in aqueous media opens a controversial discussion based on Bronsted-type plots analysis. The first approach based on the kinetic data reveals a non-catalyzed pathway. Then, the subtlety of the mathematical treatment of the kinetic data is discussed over a concerted or stepwise mechanism, respectively.

Más información

Título según WOS: Experimental Analyses Emphasize the Stability of the Meisenheimer Complex in a SNAr Reaction Toward Trends in Reaction Pathways
Título de la Revista: FRONTIERS IN CHEMISTRY
Volumen: 8
Editorial: FRONTIERS MEDIA SA
Fecha de publicación: 2020
DOI:

10.3389/fchem.2020.00583

Notas: ISI