Dereplication of pentacyclic triterpenoidls in plants by GC-EI/MS

Gu, JQ; Wang, YH; Franzblau, SG; Montenegro,G.; Timmermann, BN

Abstract

Three common plant-derived pentacyclic triterpenoids, oleanolic acid (1), betulinic acid (2) and ursolic acid (3), have been found to exhibit moderate anti-tubercular activity in a microplate alamar blue assay. In order to facilitate the discovery of novel anti-tubercular leads with diverse chemical structures, a new and rapid GC-EI/MS method was developed simultaneously and unambiguously to dereplicate 1-3 as their methyl esters with limits of detection of 25.6, 26.9 and 26.8 ng, respectively. Copyright © 2005 John Wiley & Sons, Ltd.

Más información

Título según WOS: Dereplication of pentacyclic triterpenoidls in plants by GC-EI/MS
Título según SCOPUS: Dereplication of pentacyclic triterpenoids in plants by GC-EI/MS
Título de la Revista: PHYTOCHEMICAL ANALYSIS
Volumen: 17
Número: 2
Editorial: Wiley
Fecha de publicación: 2006
Página de inicio: 102
Página final: 106
Idioma: English
URL: http://doi.wiley.com/10.1002/pca.892
DOI:

10.1002/pca.892

Notas: ISI, SCOPUS