Abstract

Buddleja globosa Hope (Buddlejaceae) is a native species cultivated in Chile, Peru, and Argentina. In folk medicine, this plant is frequently used for the treatment of different wounds (internal and external), as well as intestinal and liver diseases. There is growing scientific evidence on the growing conditions for Buddleja globosa and how its cultivation could be optimized. Methods for its vegetative propagation have also been successfully elaborated. The leaves contain phenylpropanoids, iridoids, terpenes, and flavonoids. Ethnopharmacological validation studies suggest that phenylpropanoids and flavonoids are the main and most important compounds in defining the therapeutic activity of Buddleja globosa. This chemical composition explains its pharmacological activity as antioxidant, anti-inflammatory, antimicrobial, and, in particular, its wound-healing effects. Due to its undeniable potential as a domesticated, cultivated medicinal plant and its remarkable chemical composition, it is still necessary to develop its properly standardized, clinically validated phytopharmaceutical products.