Biomarker Discovery in Patients with Immunotherapy-Treated Melanoma with Imaging Mass Cytometry

Martinez-Morilla, Sandra; Villarroel-Espindola, Franz; Wong, Pok Fai; Toki, Maria, I; Aung, Thazin Nwe; Pelekanou, Vasiliki; Bourke-Martin, Brian; Schalper, Kurt A.; Kluger, Harriet M.; Rimm, David L.

Abstract

Purpose: Imaging mass cytometry (IMC) is among the first tools with the capacity for multiplex analysis of more than 40 targets, which provides a novel approach to biomarker discovery. Here, we used IMC to characterize the tumor microenvironment of patients with metastatic melanoma who received immunotherapy in efforts to find indicative factors of treatment response. In spite of the new power of IMC, the image analysis aspects are still limited by the challenges of cell segmentation.

Más información

Título según WOS: Biomarker Discovery in Patients with Immunotherapy-Treated Melanoma with Imaging Mass Cytometry
Título de la Revista: CLINICAL CANCER RESEARCH
Volumen: 27
Número: 7
Editorial: AMER ASSOC CANCER RESEARCH
Fecha de publicación: 2021
Página de inicio: 1987
Página final: 1996
DOI:

10.1158/1078-0432.CCR-20-3340

Notas: ISI