The role of thyroid hormone calorigenesis in the redox regulation of gene expression

Varela, P; Tapia, G; Fernández V.; Videla LA.

Abstract

"Thyroid hormone (TH; 3,3',5-triiodothyronine, T3) is required for the normal function of most tissues, with major effects on 0(2) consumption and metabolic rate. These are due to transcriptional activation of respiratory genes through the interaction of T3-liganded TH receptors with TH response elements or the activation of intermediate factors, with the consequent higher production of reactive 0(2) species (ROS) and antioxidant depletion. T3-induced oxidative stress in the liver triggers the redox upregulation of the expression of cytokines (tumor necrosis factor-

Más información

Título según WOS: The role of thyroid hormone calorigenesis in the redox regulation of gene expression
Título según SCOPUS: The role of thyroid hormone calorigenesis in the redox regulation of gene expression
Título según SCIELO: The role of thyroid hormone calorigenesis in the redox regulation of gene expression
Título de la Revista: BIOLOGICAL RESEARCH
Volumen: 39
Número: 4
Editorial: Springer Nature
Fecha de publicación: 2006
Página de inicio: 611
Página final: 617
Idioma: English
DOI:

10.4067/S0716-97602006000500004

Notas: ISI, SCIELO, SCOPUS