Abstract

This paper fortifies the idea of smart drug vehicles, by exploring nickel ferrite nanoparticles. The material is made smart by covering with a novel biocompatible dextran fastened with a hydrophobic cavity containing molecule, beta-cyclodextrin (beta-CD). The approximately 6 nm MNPs, embodied with the beta-CD-dextran conjugate, permit a sustained in vitro release of camptothecin. Cytotoxicity studies are done on HaCaT, 3T3, HeLa, MDA-MB-231, and A549 cell lines. It is fascinating the stacked camptothecin indicates upgraded viability against cancer cells, rendering the nanocarrier viable for transporting the anticancer drug. (C) 2019 Elsevier B.V. All rights reserved.