Establishment and Stability of the Murine Oral Microbiome

Abusleme, L.; O'Gorman, H.; Dutzan, N.; Greenwell-Wild, T.; Moutsopoulos, N. M.

Abstract

Commensal microbiomes exert critical functions at barrier sites. In particular, establishment of the commensal microbiome after birth dictates immune functionality and tissue homeostasis at mucosal surfaces. To investigate the establishment and stability of the oral mucosal microbiome in mice, we evaluated oral microbiome communities shortly after birth, through adulthood, and up to 1 y of life in a controlled manner, using sequential oral samples from the same mice over time. We further evaluated transmissibility of oral microbiomes from parents and during cohousing experiments and evaluated susceptibility to oral inflammatory disease in mice harboring distinct microbiomes. Our work reveals basic principles in the establishment and stability of a health-associated oral microbiome after birth and provides insights that may be important for host-microbiome experimentation in animal models.

Más información

Título según WOS: Establishment and Stability of the Murine Oral Microbiome
Título de la Revista: JOURNAL OF DENTAL RESEARCH
Volumen: 99
Número: 6
Editorial: SAGE PUBLICATIONS INC
Fecha de publicación: 2020
Página de inicio: 721
Página final: 729
DOI:

10.1177/0022034520915485

Notas: ISI