Therapeutic Potential of Isoflavones with an Emphasis on Daidzein
Abstract
Daidzein is a phytoestrogen isoflavone found in soybeans and other legumes. The chemical composition of daidzein is analogous to mammalian estrogens, and it could be useful with a dual-directional purpose by substituting/hindering with estrogen and estrogen receptor (ER) complex. Hence, daidzein puts forth shielding effects against a great number of diseases, especially those associated with the control of estrogen, such as breast cancer, diabetes, osteoporosis, and cardiovascular disease. However, daidzein also has other ER-independent biological activities, such as oxidative damage reduction acting as an antioxidant, immune regulator as an anti-inflammatory agent, and apoptosis regulation, directly linked to its potential anticancer effects. In this sense, the present review is aimed at providing a deepen analysis of daidzein pharmacodynamics and its implications in human health, from its best-known effects alleviating postmenopausal symptoms to its potential anticancer and antiaging properties.
Más información
Título según WOS: | Therapeutic Potential of Isoflavones with an Emphasis on Daidzein |
Título de la Revista: | OXIDATIVE MEDICINE AND CELLULAR LONGEVITY |
Volumen: | 2021 |
Editorial: | HINDAWI LTD |
Fecha de publicación: | 2021 |
DOI: |
10.1155/2021/6331630 |
Notas: | ISI |