Article ISI
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY  (2021)

Canine osteosarcoma checkpoint expression correlates with metastasis and T-cell infiltrate

Cascio, Matthew J.; Whitley, Elizabeth M.; Chang, Lung-Ji; Cowart, Jonathan; Sayour, Elias; Dark, Michael; Sandoval, Zachary; Mitchell, Duane A.

Abstract

Background: Immune-targeted therapies are being successfully implemented into cancer clinical practice. In particular checkpoint inhibitors are employed to modulate the immune microenvironment of solid tumors. We sought to determine the expression of PD-L1, HVEM, and B7H3 in human and canine osteosarcoma, and correlate expression with clinical features and tumor infiltrating lymphocytes in naturally-occurring canine osteosarcoma.

Más información

Título según WOS: Canine osteosarcoma checkpoint expression correlates with metastasis and T-cell infiltrate
Título de la Revista: VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
Volumen: 232
Editorial: Elsevier
Fecha de publicación: 2021
DOI:

10.1016/J.VETIMM.2020.110169
Notas: ISI