Immunomodulatory and Antioxidant Activities of Sulfated Polysaccharides from Laminaria ochroleuca, Porphyra umbilicalis, and Gelidium corneum

Abdala Diaz, Roberto T.; Casas Arrojo, V; Arrojo Agudo, M. A.; Cardenas, C.; Dobretsov, S.; Figueroa, F. L.

Abstract

Seaweeds of the genera Laminaria, Gelidium, and Porphyra have been used in both food and non-food industries due to their unique properties and characteristic biological activity. This study assesses the antioxidant activity and immunomodulatory properties of the acidic polysaccharides extracted from Laminaria ochroleuca, Porphyra umbilicalis, and Gelidium corneum collected in the Atlantic coast of Tarifa (Cadiz, Spain). The proliferation of murine cell line RAW 264 decreased with increasing concentration of polysaccharides of the three algal species. The highest both antioxidant (25.69 mu mol TE g(-1) DW) and immunomodulatory activities were observed in the sulfated polysaccharides of L. ochroleuca compared to that of P. umbilicalis and G. corneum. Sulfated polysaccharides of L. ochroleuca presented high potential anticancer activity in cell lines of human colon cancer HTC-116 (IC50 = 0.44 mg mL(-1)), human malignant melanoma G-361 (IC50 = 5.42 mg mL(-1)), breast adenocarcinoma human MCF-7 (IC50 = 8.32 mg mL(-1)), and human leukemia U-937 (IC50 = 3.72 mg mL(-1)). It is concluded that metabolites of L. ochroleuca can offer significant advantages for the pharmaceutical industry, particularly when macrophage activation is required.

Más información

Título según WOS: ID WOS:000478761800012 Not found in local WOS DB
Título de la Revista: MARINE BIOTECHNOLOGY
Volumen: 21
Número: 4
Editorial: Springer
Fecha de publicación: 2019
Página de inicio: 577
Página final: 587
DOI:

10.1007/s10126-019-09905-x

Notas: ISI