The Heteromeric Complex Formed by Dopamine Receptor D-5 and CCR9 Leads the Gut Homing of CD4(+) T Cells Upon Inflammation

Osorio-Barrios, Francisco; Navarro, Gemma; Campos, Javier; Ugalde, Valentina; Prado, Carolina; Raich, Lu; Contreras, Francisco; Lopez, Ernesto; Espinoza, Alexandra; Lladser, Alvaro; Franco, Rafael; Pacheco, Rodrigo

Abstract

BACKGROUND AND AIMS: CD4(+) T cells constitute central players in inflammatory bowel diseases (IBDs), driving inflammation in the gut mucosa. Current evidence indicates that CCR9 and the integrin alpha 4 beta 7 are necessary and sufficient to imprint colonic homing on CD4(+) T cells upon inflammation. Interestingly, dopaminergic signaling has been previously involved in leukocyte homing. Despite dopamine levels are strongly reduced in the inflamed gut mucosa, the role of dopamine in the gut homing of T cells remains unknown. Here, we study how dopaminergic signaling affects T cells upon gut inflammation.

Más información

Título según WOS: The Heteromeric Complex Formed by Dopamine Receptor D-5 and CCR9 Leads the Gut Homing of CD4(+) T Cells Upon Inflammation
Título de la Revista: CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
Volumen: 12
Número: 2
Editorial: ELSEVIER INC
Fecha de publicación: 2021
Página de inicio: 489
Página final: 506
DOI:

10.1016/J.JCMGH.2021.04.006

Notas: ISI