Article ISI
NATURE MEDICINE  (2022)

Immunopathological signatures in multisystem inflammatory syndrome in children and pediatric COVID-19

Sacco, Keith; Castagnoli, Riccardo; Vakkilainen, Svetlana; Liu, Can; Delmonte, Ottavia M.; Oguz, Cihan; Kaplan, Ian M.; Alehashemi, Sara; Burbelo, Peter D.; Bhuyan, Farzana; de Jesus, Adriana A.; Dobbs, Kerry; Cheng, Aristine; Shaw, Elana; Vakkilainen, Mikko S.; et. al.

Abstract

Transcriptomic, proteomic and immune repertoire profiling reveals distinct peripheral features of MIS-C and pediatric COVID-19, including elevated soluble spike protein levels, more pronounced type II IFN-dependent gene expression and a higher B cell mutation rate in patients with MIS-C.

Más información

Título según WOS: Immunopathological signatures in multisystem inflammatory syndrome in children and pediatric COVID-19
Título de la Revista: NATURE MEDICINE
Editorial: NATURE PORTFOLIO
Fecha de publicación: 2022
DOI:

10.1038/S41591-022-01724-3
Notas: ISI