Gold nanoparticles for selective and remote heating of beta-amyloid protein aggregates

Bastus, NG; Kogan, MJ; Amigo, R.; Grillo-Bosch, D; Araya, E.; Turiel, A; Labarta, A; Giralt E.; Puntes, VF

Abstract

Nanoparticles can be made to respond resonantly to a time-varying electromagnetic field with advantageous results related to the transfer of energy from the exciting field to the nanoparticles. The surface of each particle can be heated up, this heat being transmitted into the immediately surrounding tissue. This enables their use as hyperthermia agents delivering toxic amounts of thermal energy to targeted bodies such as tumours. Heating of nanoparticles in a magnetic field is mainly due to inductive coupling (via eddy currents), and in the case of magnetic particles, loss processes during the reorientation of the magnetization (hysteresis losses) or frictional losses (relaxational losses) if the particle can rotate in an environment of sufficiently low viscosity. We use this method to apply heat locally and remotely, dissolving toxic protein deposits of Aβ1-42 (amyloid deposits) via the combined use of weak microwave fields and gold nanoparticles (AuNP) without any bulk heating. This method can be extended to a number of systems where it may be desirable to remove proteins and other aggregates involved in different pathologies. © 2006 Elsevier B.V. All rights reserved.

Más información

Título según WOS: Gold nanoparticles for selective and remote heating of beta-amyloid protein aggregates
Título según SCOPUS: Gold nanoparticles for selective and remote heating of ß-amyloid protein aggregates
Título de la Revista: MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volumen: 27
Número: 05-ago
Editorial: Elsevier
Fecha de publicación: 2007
Página de inicio: 1236
Página final: 1240
Idioma: English
URL: http://linkinghub.elsevier.com/retrieve/pii/S0928493106002773
DOI:

10.1016/j.msec.2006.08.003

Notas: ISI, SCOPUS