Abstract

This study aimed to analyze the relationship between the variability of gene OXTR, rs53576 and personality variation in a women population during fertility decline and to determine how the childhood trauma can moderate the association between genetic variation and personality. Two hundred twenty-four Chilean women participated of this study (mean age 55 y; SD 6,2 y). All women provided buccal mucosa on cotton swabs for DNA analyses and 2 questionnaires that assessed personality traits and childhood trauma events. Personality was assessed with the Big Five Inventory (BFI) and the childhood trauma with the Early Trauma Inventory Self Report-Short Form (ETISR-SF). Our model included the OXTR genotype and the trauma events subscales as independent variables of the extraversion and neuroticism, given that these personality dimensions presented significant results in previous studies. The overall model was significant, and the results indicated that the OXTR genotypes GA and GG, are significant predictors of extraversion, but not the total trauma events. In relation to neuroticism, the overall model was significant. The trauma events were significant predictors of neuroticism, but not the OXTR genotype. This study shows an association between childhood trauma events and neuroticism and between rs53576 genotype and extraversion. (CONICYT PIA-CCTE AFB170008-IEB)