Study of dissolution behavior of matrices tablets based on alginate-gelatin mixtures as prolonged diltiazem hydrochloride release systems

Tapia C.; Ormazabal, V; Costa E.; Yazdani-Pedram, M

Abstract

The aim of this work was to develop prolonged diltiazem hydrochloride release matrices based on alginate-gelatin mixtures and establish the drug release mechanism. The erosion, swelling, and dissolution behavior of the tablets in different medium were evaluated. The different polyelectrolyte behavior and gel strength between type A Gelatin and type B Gelatin would explain the different swelling, erosion and dissolution behavior in the media with sudden pH change. The similar dissolution behavior in the pH, which simulates the physiological pH through the gastrointestinal tract, should be explained because the same main species for gelatin A and Gelatin B would be present in this media. Copyright © Informa Healthcare.

Más información

Título según WOS: Study of dissolution behavior of matrices tablets based on alginate-gelatin mixtures as prolonged diltiazem hydrochloride release systems
Título según SCOPUS: Study of dissolution behavior of matrices tablets based on alginate - Gelatin mixtures as prolonged diltiazem hydrochloride release systems
Título de la Revista: DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
Volumen: 33
Número: 6
Editorial: Informa Healthcare
Fecha de publicación: 2007
Página de inicio: 585
Página final: 593
Idioma: English
URL: http://www.informapharmascience.com/doi/abs/10.1080/03639040601085359
DOI:

10.1080/03639040601085359

Notas: ISI, SCOPUS