Plasma adiponectin concentrations in non-pregnant, normal and overweight pregnant women

Nien JK; Mazaki-Tovi, S; Romero R.; Erez O.; Kusanovic, JP; Gotsch, F; Pineles, BL; Gomez, R; Edwin, S; Mazor M.; Espinoza J.; Yoon, BH; Hassan, SS

Abstract

Aims: Adiponectin is an adipokine that has anti-diabetic, anti-atherogenic, anti-inflammatory and angiogenic properties. This hormone has been implicated in both the physiological adaptation to normal pregnancy and in obstetrical complications. The aims of this study were to determine normal maternal plasma concentrations of adiponectin throughout gestation and to explore the relationships between plasma adiponectin concentration, pregnancy, and maternal overweight. Methods: A cross-sectional study was designed to include normal pregnant (normal weight and overweight; 11-42 weeks of gestation), and non-pregnant women. Plasma adiponectin concentration was determined by immunoassay. Non-parametric statistics were used for analysis. Results: (1) Adiponectin was detectable in the plasma of all patients; (2) there was no significant differences in the median adiponectin concentration between pregnant and non-pregnant women; (3) plasma adiponectin concentrations were negatively correlated with gestational age only among normal weight pregnant women; and (4) overweight patients had significantly lower plasma adiponectin concentrations than normal weight women. Conclusions: Consistent with the increased insulin resistance and weight gain that occur in pregnancy, adiponectin concentrations were negatively correlated with gestational age. The results of this study and the nomogram herein presented, can serve as the basis to explore the relationship between adiponectin and pregnancy complications and facilitate the clinical use of this important adipokine. © 2007 by Walter de Gruyter.

Más información

Título según WOS: Plasma adiponectin concentrations in non-pregnant, normal and overweight pregnant women
Título según SCOPUS: Plasma adiponectin concentrations in non-pregnant, normal and overweight pregnant women
Título de la Revista: JOURNAL OF PERINATAL MEDICINE
Volumen: 35
Número: 6
Editorial: WALTER DE GRUYTER GMBH
Fecha de publicación: 2007
Página de inicio: 522
Página final: 531
Idioma: English
URL: http://www.degruyter.com/view/j/jpme.2007.35.issue-6/jpm.2007.123/jpm.2007.123.xml
DOI:

10.1515/JPM.2007.123

Notas: ISI, SCOPUS