Abstract

Introducction: Aging is a progressive deterioration of physiological functions affecting regions as the hippocampus, altering directly the spatial memory functions. One factors that contributes to hippocampal deterioration is the decrease of mitochondrial function, generating a deficiency in energy production (Jara et al., 2019). Notably, the improvement of the mitochondrial function has possitive effects on spatial memory. Under this context, KDELR is a Golgi-located GPCR which activate a Gs-dependent PKA signaling (Pulvirenti et al., 2000 Giannotta et al., 2012 and Cancino et al., 2014). This signaling triggers a response in several organelles across the Gs / PKA pathway (Cancino et al., 2014) which, coordinates a response between ER, Golgi, Lysosomes and autophagy to modulate lipid droplet turnover. This KDELR-dependent regulation strongly suggest that mitochondrial energy metabolism could be regulated by this signaling pathways starting from the Golgi complex. Hence, we have proposed the KDELR as a new mitochondrial regulator,that could be used to promote the mitochondrial function in the hippocampal neurons and prevent the spatial memory loss.