Cancer and brassinosteroids: Mechanisms of action, SAR and future perspectives

Lorca, Marcos; Cabezas, David; Araque, Ileana; Teran, Andres; Hernandez, Santiago; Mellado, Marco; Espinoza, Luis; Mella, Jaime

Abstract

Brassinosteroids are plant hormones whose main function is to stimulate plant growth. However, they have been studied for their biological applications in humans. Brassinosteroid compounds have displayed an important role in the study of cancer pathology and show potential for developing novel anticancer drugs. In this review we describe the relationship of brassinosteroids with cancer with focus on the last decade, the mechanisms of cytotoxic activity described to date, and a structure-activity relationship based on the available information.

Más información

Título según WOS: Cancer and brassinosteroids: Mechanisms of action, SAR and future perspectives
Título de la Revista: STEROIDS
Volumen: 190
Editorial: Elsevier Science Inc.
Fecha de publicación: 2023
DOI:

10.1016/j.steroids.2022.109153

Notas: ISI