Therapeutic potential of polyphenols in cardiovascular diseases: Regulation of mTOR signaling pathway

Sanches-Silva, Ana; Testai, Lara; Nabavi, Seyed Fazel; Battino, Maurizio; Devi, Kasi Pandima; Tejada, Silvia; Sureda, Antoni; Xu, Suowen; Yousefi, Bahman; Majidinia, Maryam; Russo, Gian Luigi; Efferth, Thomas; Nabavi, Seyed Mohammad; Farzaei, Mohammad Hossein

Abstract

Cardiovascular diseases comprise of non-communicable disorders that involve the heart and/or blood vessels and have become the leading cause of death worldwide with increased prevalence by age. mTOR is a serine/threonine-specific protein kinase which plays a central role in many physiological processes including cardiovascular diseases, and also integrates various proliferative signals, nutrient and energy abundance and stressful situations. mTOR also acts as central regulator during chronic stress, mitochondrial dysfunction and deregulated autophagy which are associated with senescence. Under oxidative stress, mTOR has been reported to exert protective effects regulating apoptosis and autophagy processes and favoring tissue repair. On the other hand, inhibition of mTOR has been suggested to have beneficial effects against atherosclerosis, cardiac hypertrophy and heart failure, and also in extending the lifespan. In this aspect, the use of drugs or natural compounds, which can target mTOR is an interesting approach in order to reduce the number of deaths caused by cardiovascular disease. In the present review, we intend to shed light on the possible effects and molecular mechanism of natural agents like polyphenols via regulating mTOR.

Más información

Título según WOS: ID WOS:000518700200011 Not found in local WOS DB
Título de la Revista: PHARMACOLOGICAL RESEARCH
Volumen: 152
Editorial: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
Fecha de publicación: 2020
DOI:

10.1016/j.phrs.2019.104626

Notas: ISI