Abstract

Typically, the fundamental assumption in non-linear regression models is the normality of the errors. Even though this model offers great flexibility for modeling these effects, it suffers from the same lack of robustness against departures from distributional assumptions as other statistical models based on the Gaussian distribution. It is of practical interest, therefore, to study non-linear models which are less sensitive to departures from normality, as well as related assumptions. Thus the current methods proposed for linear regression models need to be extended to non-linear regression models. This paper discusses non-linear regression models for longitudinal data with errors that follow a skew-elliptical distribution. Additionally, we discuss Bayesian statistical methods for the classification of observations into two or more groups based on skew-models for non-linear longitudinal profiles. Parameter estimation for a discriminant model that classifies individuals into distinct predefined groups or populations uses appropriate posterior simulation schemes. The methods are illustrated with data from a study involving 173 pregnant women. The main objective in this study is to predict normal versus abnormal pregnancy outcomes from beta human chorionic gonadotropin data available at early stages of pregnancy. © 2008 Elsevier B.V. All rights reserved.