Abstract

For decades, Enterococcus faecalis has been considered as the most common microorganism associated with post-treatment endodontic infections, as well as the bacterial isolate most commonly recovered from the root canal.1 Enterococcus faecalis is an anaerobic aerotolerant, motile, and spore-forming Gram-positive bacterium, arranged in pair or short chains. Its metabolic activity gives this bacterium the ability to survive for long periods in root canals under very unfavorable conditions, such as alkaline or nutrient-limited environments. Ultimately, all the approaches that incorporate metagenomes with metaproteomes and metabolomes (multi-omics) could represent the key to unravel the complex network of alliances between bacterial communities, their pathogenicity, and host responses.