Abstract

Nanotechnology is a strategy that has been in the spotlight in recent decades, due to its innovative and functional properties. Nanoparticles (NPs) are defined as submicroscopic particles between 1 and 100 nm in size. It has been observed that NPs can potentially improve the therapeutic efficacy of pharmaceutical products by promoting better bioavailability, serum stability, and drug pharmacokinetics. According to the literature, nano-formulations provide better penetration and allow the slow and controlled release of active ingredients at the target sites.3 The most important characteristic of NPs is their large external surface area, as well as their high surface to volume ratio, factors that determine their physicochemical properties. The use of aPDT associated with photosensitizing agents encapsulated in nanoparticles of different origins opens a new way to combat bacterial infections within the root canal system. So far, the reported results are promising and point to the activation of nanoencapsulated photosensitizing agents as a promising antimicrobial alternative in the endodontic field.