Abstract

Krüppel-like factors, (KLF)s are transcription factorsthat possess finger-like zinc structures binding toDNA; families of these transcription factors include18 members that can bind to consensus DNAsequences, CACCC, and sites rich in GC sequences.KLFs can act as activators or repressors of genetranscription related to a wide variety of physiologicalprocesses including but not limited to cell cycleregulation, differentiation, and apoptosis. Thus,deregulation in these transcription factors is involvedin pathologies such as endometrial, ovarian, colon,and metabolic diseases of the pancreas, liver, andheart muscle. To initiate these physiological andpathological events, members of KLFs interactwith ligand-activated nuclear receptors such asPeroxisome Proliferator-Activated Receptor Gamma,(PPARγ) or PPAR; this has been observed inoverexpression and activation of the PPAR receptorexperiments. In previous studies, it was foundthat, compared to treatment with agonists fromPPARγ, KLF6 is overexpressed in Caco-2 coloncancer cell lines. Therefore, the objective of thisreview article is to show the possible functionalrelationship that exists between different members ofKLFs and PPARγ, in normal and pathological states.