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Enhanced contacts between lysosome and mitochondria as a key pathogenic pathway in neuronopathic Gaucher Disease
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| Fecha de publicación: | 2023 |
| Objetivos: | 1. To demonstrate an increase in the number of lysosome-mitochondria contact sites; 2. To determine if there is an increase in STARD3-mediated transfer of cholesterol from lysosomes to mitochondria at the contact sites; 3. To evaluate the effect of inhibiting STARD3 expression and c-Abl in vivo. |
| Programa: | FONDECYT |
| Año de Inicio/Término: | 2023-2027 |
| Financiamiento/Sponsor: | CONICYT |
| Rol del Usuario: | INVESTIGADOR(A) RESPONSABLE |
| DOI: |
1230337 |