Central nervous system networks involved in the processing of meningeal and cutaneous inputs from the ophthalmic branch of the trigeminal nerve in the rat

Noseda R; Monconduit, L; Constandil, L; Chalus M; Villanueva, L

Abstract

This study analysed the organization of central nervous system networks involved in the processing of meningeal inputs in the male, Sprague-Dawley rat. We injected the anterograde tracer, biotin dextran, into areas of the medullary trigeminal nucleus caudalis (Sp5C), which receive inputs from the ophthalmic division of the trigeminal nerve. Double-labelling immunohistochemical studies were then performed to compare calcitonin gene-related peptide (CGRP) or serotonin 1D (5HT1D) receptor distributions in the areas innervated by Sp5C neurons. Dense, topographically organized intratrigeminal connections were observed. Sp5C neurons projected to the commissural subnucleus of the solitary tract, A5 cell group region/superior salivatory nucleus, lateral periaqueductal grey matter, inferior colliculus and parabrachial nuclei. Trigeminothalamic affer- ents were restricted to the posterior group and ventroposteromedial thalamic nuclei. Some of these areas are also immunoreactive for 5HT1 D and CGRP and thus remain potential central targets of triptan molecules and other antimigraine drugs. © Blackwell Publishing Ltd Cephalalgia, 2008.

Más información

Título según WOS: Central nervous system networks involved in the processing of meningeal and cutaneous inputs from the ophthalmic branch of the trigeminal nerve in the rat
Título según SCOPUS: Central nervous system networks involved in the processing of meningeal and cutaneous inputs from the ophthalmic branch of the trigeminal nerve in the rat
Título de la Revista: CEPHALALGIA
Volumen: 28
Número: 8
Editorial: SAGE PUBLICATIONS LTD
Fecha de publicación: 2008
Página de inicio: 813
Página final: 824
Idioma: English
URL: http://cep.sagepub.com/cgi/doi/10.1111/j.1468-2982.2008.01588.x
DOI:

10.1111/j.1468-2982.2008.01588.x

Notas: ISI, SCOPUS