Abstract

In the current study, the solubility of famotidine (FAM) in supercritical carbon dioxide (scCO?) was experimentally determined for the first time. The FAM solubility in scCO?, expressed as mole fraction, at different temperatures (308 ? 338 K) and pressures (12 ? 30 MPa) was found to be in the range of 1.40 × 10?6 to 1.11 × 10?4. Due to the low solubility of FAM in scCO?, the gas anti-solvent and supercritical anti-solvent processes can be a good option to generate the nano/micro size particles of this drug. The experimental solubility data were correlated by the density-based models of Bartle et al., Méndez-Santiago and Teja (MST), Jouyban et al. and Hozhabr et al., by the non-cubic equation of state PC-SAFT, and by the two versions of the Estévez et al. model (ECM-PR and ECM-RK). According to the modeling results, the Estévez et al. model showed the highest accuracy with AARD values of 9.92 (ECM-PR) and 10.70 (ECM-RK). The empirical models also yielded satisfactory outcomes to the correlation of the solubility of FAM in scCO?. © 2023 Elsevier B.V.