Deep Learning for Basal Cell Carcinoma Detection for Reflectance Confocal Microscopy

Campanella, Gabriele; Navarrete-Dechent, Cristian; Liopyris, Konstantinos; Monnier, Jilliana; Aleissa, Saud; Minhas, Brahmteg; Scope, Alon; Longo, Caterina; Guitera, Pascale; Pellacani, Giovanni; Kose, Kivanc; Halpern, Allan C.; Fuchs, Thomas J.; Jain, Manu

Abstract

Basal cell carcinoma (BCC) is the most common skin cancer, with over 2 million cases diagnosed annually in the UnitedStates. Conventionally, BCC is diagnosed by naked eye examination and dermoscopy. Suspicious lesions are either removed or biopsied for histopathological confirmation, thus lowering the specificity of noninvasive BCC diagnosis. Recently, reflectance confocal microscopy, a noninvasive diagnostic technique that can image skin lesions at cellular level resolution, has shown to improve specificity in BCC diagnosis and reduced the number needed to biopsy by 2-3 times. In this study, we developed and evaluated a deep learning-based artificial intelligence model to automatically detect BCC in reflectance confocal microscopy images. The proposed model achieved an area under the curve for the receiver operator characteristic curve of 89.7%(stack level) and 88.3%(lesion level), a performance on par with that of reflectance confocal microscopy experts. Furthermore, themodel achieved an area under the curve of 86.1% on a held-out test set from international collaborators, demonstrating the reproducibility and generalizability of the proposed automated diagnostic approach. These results provide a clear indication that the clinical deployment of decision support systems for the detection of BCC in reflectance confocal microscopy images has the potential for optimizing the evaluation and diagnosis of patients with skin cancer.

Más información

Título según WOS: Deep Learning for Basal Cell Carcinoma Detection for Reflectance Confocal Microscopy
Título de la Revista: JOURNAL OF INVESTIGATIVE DERMATOLOGY
Volumen: 142
Número: 1
Editorial: Elsevier Science Inc.
Fecha de publicación: 2022
Página de inicio: 97
Página final: 103
DOI:

10.1016/j.jid.2021.06.015

Notas: ISI