Abstract

Question What is the utility of multiple aggregated yellow-white globules, a newly described dermoscopic feature, for the diagnosis of basal cell carcinoma? Findings In this case-control study of 656 lesions in 643 patients (291 basal cell carcinomas in 278 patients [cases] and 365 other diagnoses in 365 patients [controls]), the presence of multiple aggregated yellow-white globules was associated with a diagnosis of nonpigmented basal cell carcinoma and high-risk histologic subtypes of basal cell carcinoma. Meaning The presence of multiple aggregated yellow-white globules may aid the diagnosis of nonpigmented basal cell carcinoma, particularly high-risk subtypes on the head and neck.