Abstract

This systematic review aimed to describe the effects of antioxidant treatments after alcohol exposure in humans and in vitro models. A systematic review of quantitative studies to identify the effectiveness of antioxidant treatments on CYP2E1 activity after alcohol consumption. Multiple databases were searched from 2010 to May 2020 for studies in English, using MeSH terms and text words relating to antioxidant treatments, CYP2E1 and, alcohol consumption. The protocol is registered on PROSPERO CRD42021226123. Study quality was assessed using the NICE methodology. The review is reported according to PRISMA. A total of eight original articles were analyzed. All papers collected and reported quantitative data. Antioxidant treatments could be beneficial after alcohol exposure to improve oxidative stress by decreasing CYP2E1 activity and increasing GSH levels. Our results suggest that antioxidant treatments could be beneficial and effective during ethanol exposure in human or in vitro models.