Article ISI SCOPUS
BIOORGANIC & MEDICINAL CHEMISTRY  (2008)

Structure-reactivity relationships for electrophilic sugars in interaction with nucleophilic biological targets

Campodonico, PR; Contreras R.

Abstract

The global electrophilicity index that incorporates electrostatic and polarizability contributions shows a quantitative correlation with antiviral and cytotoxic activities of electrophilic sugars. The model is applied to a series of compounds that behave as Michael acceptors in interaction with biological nucleophilic targets. © 2007 Elsevier Ltd. All rights reserved.

Más información

Título según WOS: Structure-reactivity relationships for electrophilic sugars in interaction with nucleophilic biological targets
Título según SCOPUS: Structure-reactivity relationships for electrophilic sugars in interaction with nucleophilic biological targets
Título de la Revista: BIOORGANIC & MEDICINAL CHEMISTRY
Volumen: 16
Número: 6
Editorial: PERGAMON-ELSEVIER SCIENCE LTD
Fecha de publicación: 2008
Página de inicio: 3184
Página final: 3190
Idioma: English
URL: http://linkinghub.elsevier.com/retrieve/pii/S0968089607010723
DOI:

10.1016/j.bmc.2007.12.018
Notas: ISI, SCOPUS