Abstract

Aromaticity is a useful tool to rationalize the structure, stability, and reactivity in several compounds. Although aromaticity is not directly an observable, it is well accepted that electronic delocalization around the molecular ring is a key stabilizing feature of aromatic compounds. This contribution presents a systematic evaluation of the capability of delocalization and reactivity criteria to describe aromaticity in a set of fluorinated benzenes. The aromaticity indices are compared with quantities obtained from the magnetic criteria of aromaticity, i.e., the strength of the ring current induced by an external magnetic field and the popular NICSzz(1) index. In this evaluation, the indices based on delocalization criteria used are aromatic fluctuation index (FLU), para-delocalization index (PDI), PDI pi, and the multicenter delocalization index (MCI). In addition, indices based on the bifurcation values of scalar functions are derived from electron density such as electron localization function (the pi contribution, ELF pi) and the pi contribution of the localized orbital locator (LOL pi). Furthermore, reactivity indices based on chemical reactivity and the information-theoretic (reactivity) approach are para-linear response (PLR), Shannon entropy, Fisher information, and Ghosh-Berkowitz-Parr (GBP) entropy. The results obtained show that the delocalization-based indicators present a high sensitivity to slight changes in aromaticity and that the reactivity criterion can be considered as a complementary tool for the study of this phenomenon, even when these changes are minimal. These results encourage the use of multiple indicators for a complete understanding of aromaticity in various chemical compounds.