RhoA/rho kinase pathway activation in age-associated endothelial cell dysfunction and thrombosis
Abstract
The small GTPase RhoA and the downstream Rho kinase (ROCK) regulate several cell functions and pathological processes in the vascular system that contribute to the age-dependent risk of cardiovascular disease, including endothelial dysfunction, excessive permeability, inflammation, impaired angiogenesis, abnormal vasoconstriction, decreased nitric oxide production and apoptosis. Frailty is a loss of physiological reserve and adaptive capacity with advanced age and is accompanied by a pro-inflammatory and pro-oxidative state that promotes vascular dysfunction and thrombosis. This review summarises the role of the RhoA/Rho kinase signalling pathway in endothelial dysfunction, the acquisition of the pro-thrombotic state and vascular ageing. We also discuss the possible role of RhoA/Rho kinase signalling as a promising therapeutic target for the prevention and treatment of age-related cardiovascular disease.
Más información
Título según WOS: | ID WOS:001195998500001 Not found in local WOS DB |
Título de la Revista: | JOURNAL OF CELLULAR AND MOLECULAR MEDICINE |
Volumen: | 28 |
Número: | 8 |
Editorial: | Wiley |
Fecha de publicación: | 2024 |
DOI: |
10.1111/jcmm.18153 |
Notas: | ISI |