Article ISI
NATURE COMMUNICATIONS  (2022)

GIT1 protects against breast cancer growth through negative regulation of Notch

Zhang, Songbai; Miyakawa, Ayako; Wickstrom, Malin; Dyberg, Cecilia; Louhivuori, Lauri; Kemppainen, Kati; Kanatani, Shigeaki; Kaczynska, Dagmara; Ellstrom, Ivar Dehnisch; Elfman, Lotta; Kronqvist, Pauliina; Repo, Heli; Sahlgren, Cecilia; Johnsen, John Inge

Abstract

Notch signalling is reported to be hyperactivated in oestrogen receptor-negative (ER-) breast cancer. Here the authors show that G protein-coupled receptor kinase-interacting protein 1 (GIT1) negatively regulates Notch signalling and tumour growth in ER- breast cancer by blocking Notch ICD nuclear translocation.

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Título según WOS: GIT1 protects against breast cancer growth through negative regulation of Notch
Título de la Revista: NATURE COMMUNICATIONS
Volumen: 13
Número: 1
Editorial: BERLIN
Fecha de publicación: 2022
DOI:

10.1038/S41467-022-28631-Y
Notas: ISI