Abstract

Aim: To examine the association between physical activity and the cause of death with the greatest risk related to type 2 diabetes mellitus (T2DM) in a large population-based cohort representative of the general US adult population. Methods: A total of 41,726 adults suffering from T2DM (age 62 +/- 14 years) and 459,660 adults without diabe-tes (age 46 +/- 18 years) who participated in the National Health Interview Survey from 1997 to 2014 were included in this prospective cohort study. Self-reported moderate-to-vigorous physical activity (MVPA) was categorized into inactive, insufficiently active, active and very active. Mortality data was obtained from the National Death Index. Cox regression models adjusted for potential confounders were performed to estimate hazard ratio (HR) and 95% confidence interval (CI). Results: Diabetes mortality cause showed the highest relative risk of death among adults with T2DM com-pared to adults without diabetes (HR 5.72 [3.15;10.39]). There was a non-linear inverse dose-response asso-ciation between MVPA and diabetes mortality among adults with T2DM, up to a plateau in risk reduction at approximately 500 min/week. Any level of activity was inversely associated with a significantly lower risk of diabetes mortality compared with being inactive (insufficiently active HR 0.71[0.54;0.97], active HR 0.68 [0.49;0.95], very active HR 0.44 [0.32;0.60]). Compared to adults without diabetes, the risk of diabetes mor-tality decreased from HR 7.38 [4.00;13.58] for inactive people with T2DM to HR 3.34 [1.76;6.32] for very active people with T2DM. Conclusions: Higher levels of MVPA were associated with lower risk of diabetes mortality among adults with T2DM. (c) 2022 Elsevier Masson SAS. All rights reserved.