(E)3-2-(1-(2,4-Dihydroxyphenyl)ethyldeneamino)phenyl)-2-methylquinazoline-4(3H)-one Schiff Base and Its Metal Complexes: A New Drug of Choice against Methicillin-Resistant Staphylococcus aureus

Siddappa, K.; Mane, Sunilkumar B.; Manikprabhu, Deene

Abstract

The 3-(2-aminophenyl) quinazolin-2-methyl-4(3H)-one and 2,4-dihydroxyacetophenone undergo condensation to afford (E) 3-2-(1-(2,4-dihydroxyphenyl)ethyldeneamino)phenyl)-2-methylquinazoline-4(3H)-one Schiff base (DHPEAPMQ). The newly synthesized Schiff base (DHPEAPMQ) and its metal complexes were evaluated for their antimicrobial activity against methicillin-resistant Staphylococcus aureus isolated from the Gulbarga region in India. The Cu(II), Ni(II), and Zn(II) complexes of Schiff base (DHPEAPMQ) showed good antimicrobial activity. So, this could be a new drug of choice.

Más información

Título según WOS: ID WOS:000333303800001 Not found in local WOS DB
Título de la Revista: BIOINORGANIC CHEMISTRY AND APPLICATIONS
Volumen: 2014
Editorial: HINDAWI LTD
Fecha de publicación: 2014
DOI:

10.1155/2014/343540

Notas: ISI