Micro-RNAs: viral genome and robustness of gene expression in the host

Demongeot, J.; Drouet, E; Elena, A.; Moreira, A.; Rechoum, Y; Sené S

Abstract

For comparing RNA rings or hairpins with reference or random ring sequences, circular versions of distances and distributions like those of Hamming and Gumbel are needed. We define these circular versions and we apply these new tools to the comparison of RNA relics (such as micro-RNAs and tRNAs) with viral genomes that have coevolved with them. Then we show how robust are the regulation networks incorporating in their boundary micro-RNAs as sources or new feedback loops involving ubiquitous proteins like p53 (which is a micro-RNA transcription factor) or oligopeptides regulating protein translation. Eventually, we propose a new coevolution game between viral and host genomes. © 2009 The Royal Society.

Más información

Título según WOS: Micro-RNAs: viral genome and robustness of gene expression in the host
Título según SCOPUS: Micro-RNAs: Viral genome and robustness of gene expression in the host
Título de la Revista: PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES
Volumen: 367
Número: 1908
Editorial: ROYAL SOC
Fecha de publicación: 2009
Página de inicio: 4941
Página final: 4965
Idioma: English
URL: http://rsta.royalsocietypublishing.org/cgi/doi/10.1098/rsta.2009.0176
DOI:

10.1098/rsta.2009.0176

Notas: ISI, SCOPUS