Clathrin and AP1B: Key roles in basolateral trafficking through trans-endosomal routes

González A; Rodriguez-Boulan, E

Abstract

Research following introduction of the MDCK model system to study epithelial polarity (1978) led to an initial paradigm that posited independent roles of the trans Golgi network (TGN) and recycling endosomes (RE) in the generation of, respectively, biosynthetic and recycling routes of plasma membrane (PM) proteins to apical and basolateral PM domains. This model dominated the field for 20 years. However, studies over the past decade and the discovery of the involvement of clathrin and clathrin adaptors in protein trafficking to the basolateral PM has led to a new paradigm. TGN and RE are now believed to cooperate closely in both biosynthetic and recycling trafficking routes. Here, we critically review these recent advances and the questions that remain unanswered. © 2009 Federation of European Biochemical Societies.

Más información

Título según WOS: Clathrin and AP1B: Key roles in basolateral trafficking through trans-endosomal routes
Título según SCOPUS: Clathrin and AP1B: Key roles in basolateral trafficking through trans-endosomal routes
Título de la Revista: FEBS Letters
Volumen: 583
Número: 23
Editorial: Wiley-Blackwell
Fecha de publicación: 2009
Página de inicio: 3784
Página final: 3795
Idioma: eng
URL: http://linkinghub.elsevier.com/retrieve/pii/S0014579309008382
DOI:

10.1016/j.febslet.2009.10.050

Notas: ISI, SCOPUS