Acquired oral syphilis: A multicenter study of 339 patients from South America

de Andrade, Bruno Augusto Benevenuto; de Arruda, Jose Alcides Almeida; Gilligan, Gerardo; Piemonte, Eduardo; Panico, Rene; Molina Avila, Ignacio; Pimentel Sola, Juan Martin; Carmona Lorduy, Martha Cecilia; Pupo Marrugo, Stella; Sanchez Tatis, Angelica Sofia; Werner, Laura Cecilia; Abrahao, Aline Correa; Agostini, Michelle; Buoro, Luisa; Israel, Monica Simoes; et. al.

Abstract

Objective To report the clinicopathologic features of acquired oral syphilis cases in South American countries. Materials and Methods Clinical data were retrospectively collected from the records of 18 oral diagnostic services in Argentina, Brazil, Chile, Colombia, Venezuela, Uruguay, and Peru. Serologies of nontreponemal and treponemal tests were used for diagnosis. Results The series comprised 339 cases of acquired oral syphilis. Secondary syphilis ranked as the most common stage (86.7%). Lesions were more frequent among males (58.0%) and young adults with a mean age of 33.3 years. Individuals aged 20-29 years were most affected (35.3%). The most commonly involved sites were the tongue (31.6%), lip/labial commissure (25.1%), and hard/soft palate (20.4%). Clinically, acquired oral syphilis usually presented as mucous patches (28.4%), papules (25.7%), and ulcers (18.1%). Skin manifestations occurred in 67.7% of individuals, while lymphadenopathy and fever were observed in 61.3% and 11.6% of all subjects, respectively. Most patients were treated with the benzathine penicillin G antibiotic. Conclusion This report validates the spread of acquired oral syphilis infection among young adults in South America. Our directives include accessible diagnostic tools for proper disease screening, surveillance, and counselling of affected individuals, especially in low- and middle-income countries.

Más información

Título según WOS: Acquired oral syphilis: A multicenter study of 339 patients from South America
Título de la Revista: ORAL DISEASES
Volumen: 28
Número: 6
Editorial: Wiley
Fecha de publicación: 2022
Página de inicio: 1561
Página final: 1572
DOI:

10.1111/odi.13963

Notas: ISI