Abstract

Resveratrol is a natural phenol with anti-oxidant and anti-inflammatory activity, however it is limited by its in vivo low bioavailability and high metabolization rate. Its encapsulation in PLGA nanoparticles (NPs) can overcome such challenges. PLGA and PLGA-Resveratrol NPs optimal synthesis input variables were studied by fractional factorial and Box-Behnken design methodologies, respectively. It was found that PLGA NPs physicochemical properties were mainly affected by the amount of PLGA and PVA concentration. PLGA-Resveratrol NPs optimal synthesis, using as input variables the amount of PLGA, Resveratrol, and PVA concentration, yield a hydrodynamic diameter of 137 nm, polydispersity index of 0.195, drug loading of 16 %, and z-potential of -24.71 mV. These results are in very close agreement with the predicted values. (C) 2019 Elsevier Ltd. All rights reserved.